- The origin and evolution of Ebola and Marburg viruses.
- Molecular evolution of viruses of the family Filoviridae based on 97 whole-genome sequences.
The origin and evolution of Ebola and Marburg viruses.
Why do Bats Transmit so many Diseases like Ebola?and you denver to boulder drive time herman miller eames office chair
Skip to search form Skip to main content. Molecular evolution of viruses of the family Filoviridae based on 97 whole-genome sequences. The first documented cases occurred in primates over 45 years ago, but the amount of virus genetic diversity detected within bat populations, which have recently been identified as potential reservoir hosts, suggests that the filoviruses are much older. View PDF. Save to Library. Create Alert. Share This Paper.
Ebola and Marburg virus diseases are caused by the Ebola and Marburg viruses respectively. Both remain rare diseases, but have the potential to cause outbreaks with high case fatality rates. Ebola and Marburg viruses have caused outbreaks in the past, mostly in sub-Saharan tropical countries, notably in the central Africa region. The largest and most complex outbreak of Ebola virus disease was reported in three West African countries Guinea, Liberia and Sierra Leone from —, with over 28 cases and 11 deaths. Ebola and Marburg virus diseases are not airborne diseases and are generally considered not contagious before initial onset of symptoms. Transmission requires direct contact with blood, secretions, organs or other bodily fluids of dead or living infected persons or animals. Therefore, the risk of infection is considered very low if appropriate infection prevention and control precautions are strictly followed.
Ebola and evolution October , updated August The Ebola outbreak in West Africa has international medical organizations on high alert and people all around the world antsy — even those who live in the Americas and Australia, oceans away from the disease's epicenter. The disease is normally carried by animals like fruit bats, but occasionally makes the jump to humans, and when it does, it is deadly, killing more than half of those infected. However, because it is only spread by direct contact with bodily fluids, most of the world need not fear for their lives. In recent months, some media outlets, and even a scientist or two, have begun to wonder aloud whether the Ebola virus could " mutate " and become airborne — but of course, what is actually meant is whether the virus can evolve in ways that allow it to be passed along more easily, just as the flu can be spread by a sneeze.
The past year has marked the most devastating Ebola outbreak the world has ever witnessed, with over 28, cases and over 11, deaths. Ebola virus EBOV has now been around for almost 50 years. In this review, we discuss past and present outbreaks of EBOV and how those variants evolved over time. We explore and discuss selective pressures that drive the evolution of different Ebola variants, and how they may modify the efficacy of therapeutic treatments and vaccines currently being developed. Finally, given the unprecedented size and spread of the outbreak, as well as the extended period of replication in human hosts, specific attention is given to the — West African outbreak variant Makona.
The headlines mentioned above, though alarmist, raise important questions about the danger of these zoonoses, why they emerge, and what we can do to control them. Summary of known and predicted geography of filoviruses in Africa A Known occurrence points of filovirus hemorrhagic fevers HFs identified by virus species. B Geographic projection of ecologic niche model based on all known filovirus disease occurrences in Africa. C Geographic projection of ecologic niche model based on all known occurrences of Marburg HF. Darker shades of red represent increasing confidence in prediction of potential presence.
Molecular evolution of viruses of the family Filoviridae based on 97 whole-genome sequences.